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PEGylation chemistry and PEG reagent selection guide - This document is intended to help select proper PEGylation reagents to achieve desired properties and applications.

PEGylation books, book chapters, and review articles:

Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives, Ed. Roland Kontermann, Wiley-Blackwell, 2012; Part Two, Page 41-56, Half-Life Extension Through PEGylation.
Kang Choon Lee, Seulki Lee, What is the future of pegylated therapies? Expert Opin Emerg Drugs, 2015; 20(4): 531鈥536. Text.
Jevsevar et al, PEGylation of Therapeutic Proteins, Biotechnol. J. 2010, 5, 113鈥128. Text.
Peter L Turecek, Mary J Bossard, Freddy Schoetens, Inge A Ivens, PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs, Journal of Pharmaceutical Sciences, 2016, 105, 460-475. Text.
Liu et al, Current Drug Research on PEGylation with Small Molecule Agents, Progress in Polymer Science, 2013, 38, 421-444. Text.
Gambhir et al, Nanoparticle PEGylation for Imaging and Therapy, Nanomedicine, 2011, 6(4): 715-728. Text.
Fishburn et al, The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics. Journal of Pharmaceutical Sciences, 2008, 97: 4167-4183. Text.
Veronese et al, PEGylation: Successful Approach to Drug Delivery, Drug Discovery Today, 2005, 10(21): 1451-1458. Text.
Kataoka et al, PEGylated Nanoparticles for Biological and Pharmaceutical Applications, Advanced Drug Delivery Reviews, 2003, 55: 403-419. Text.
Harris et al, Chemistry for Peptide and Protein PEGylation, Advanced Drug Delivery Reviews, 2002, 54: 459-476. Text.
J Milton Harris, Effect of PEGylation on Pharmaceuticals, Nature Reviews Drug Discovery, 2003, 2, 214-221, doi:10.1038/nrd1033. Text.
Jim Kling, PEGylation of Biologics, BioProcess International, Vol. 11, No. 3, March 2013, pp. 34?3. Text.
Francesco M. Veronese, Peptide and Protein PEGylation: a Review of Problems and Solutions, Biomaterials, 2001, 22(5): 405-417. Text.

PEGylation procedure references:

Please visit PEGylation Literature to select proper procedures and protocols for PEGylation chemistry.

Polysaccharides Review References

Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications, Biotechnology Letters, 2007, 29(1): 17-25. Text.
Novel drug development opportunities for heparin, Nature Review Drug Discovery, 2002, 1(2): 140-148. Text.
Alginate: Properties and biomedical applications, Progress in Polymer Science, 2012, 37(1): 106-126. Text.
Dextrans for targeted and sustained delivery of therapeutic and imaging agents, Journal of Controlled Release, 2012, 69(1): 1-25. Text.
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