Reactive PEG reagents are used to derivatize, functionalize, conjugate or crosslink a variety of substrate molecules, particles and surfaces. Listed below are selected literature examples of successful PEGylation using Creative PEGWorks' PEG products.

I. PEGylation of Biologics – Proteins, Antibodies, Peptides, Nucleic Acids

II. PEGylation of Nanoparticles, Surfaces, Chips, Membranes

III. Biotin PEGylation and Biotinylation

IV. PEGylation Crosslinkers – Drug Delivery, Molecular Imaging, Biophysics

V. PEG Hydrogel – Regenerative Medicine, Tissue Engineering, Drug Delivery

VI. Self-Assembling – PEGylated Liposome, Micelle, Monolayer

VII. Small Molecule PEGylation and Miscellaneous

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PEGylation of Biologics - Proteins, Antibodies, Peptides, Nucleic Acids

mPEG-Maleimide (Thiol PEGylation of Proteins) - Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel, Biochemistry, 2012, 51 (31), pp 6195–6206, Text.

mPEG-Maleimide (Thiol PEGylation of Proteins) - The holin of bacteriophage lambda forms rings with large diameter, Molecular Microbiology, 09/2008; 69(4):784-793, Text.

mPEG-Maleimide (Thiol PEGylation of Proteins) - In vitro folding of KvAP, a voltage gated K+ channel, Biochemistry. 2011 6; 50(48): 10442–10450, Text.

mPEG-MAL (Thiol PEGylation of Cysteine Peptide) - Structure of the lethal phage pinhole, Proc Natl Acad Sci USA. 2009;106(45):18966-71, Text.

mPEG-MAL (Thiol PEGylation of Proteins) - A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells, Cell, Volume 157, Issue 7, 19 June 2014, Pages 1644–1656, Text.

mPEG-NHS (Amine PEGylation of Peptide) - High Efficiency Diffusion Molecular Retention Tumor Targeting. PLoS ONE 8(3): e58290, Text, Experimental details in SI.

mPEG-NHS (PEGylated Polymers for Gene Delivery) - BSA Nanoparticles for siRNA Delivery: Coating Effects on Nanoparticle Properties, Plasma Protein Adsorption, and In Vitro siRNA Delivery, International Journal of Biomaterials, Volume 2012, Article ID 584060, 10 pages, Text.

mPEG-SCM (Amine PEGylation of Lysine Peptide) - PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials, PLoS ONE 9(4): e95406, Text.

mPEG-SCM (Amine PEGylation of Proteins) - PEGylation of lysine residues improves the proteolytic stability of fibronectin while retaining biological activity, Biotechnol. J. 2014, 9, Text.

mPEG-Alkyne (Clickable PEGylation of Proteins) - Identification and Origin of N-Linked b-D-NAcetylglucosamine Monosaccharide Modifications on Arabidopsis Proteins. Plant Physiology, 2013, 161: 455–464, Text.

mPEG-Alkyne (Clickable PEGylation of Proteins) - Visualization of O‐GlcNAc Glycosylation Stoichiometry and Dynamics Using Resolvable Poly(ethylene glycol) Mass Tags, Current Protocols in Chemical Biology, 5:281–302, Text.

mPEG-Epoxide (Hydroxyl PEGylation of Polysaccharide) - Surface Grafting of Cellulose Nanocrystals with Poly(ethylene oxide) in Aqueous Media, Langmuir 2010, 26(16), 13450–13456, Text.

mPEG-Aminooxy (Carbonyl PEGylation of Saccharide) - Visualization of O‐GlcNAc Glycosylation Stoichiometry and Dynamics Using Resolvable Poly(ethylene glycol) Mass Tags, Current Protocols in Chemical Biology, 5:281–302, Text.

Acrylate-PEG-Acrylate (Thiol PEGylation of siRNA) - Methods and Compositions for Improved Therapeutic Effects with siRNA, Patent US20080311040 A1, Text.

4-Arm PEG-Amine (Delivery Vector for siRNA) - Multi-armed cationic cyclodextrin: poly(ethylene glycol) polyrotaxanes as efficient gene silencing vectors, Integr. Biol., 2013,5, 115-121, Text.

PEGylation of Nanoparticles, Surfaces, Chips, Membranes

mPEG-Thiol (Thiol PEGylation of Gold Nanorods) - Spatiotemporal Temperature Distribution and Cancer Cell Death in Response to Extracellular Hyperthermia Induced by Gold Nanorods, ACS Nano, 2010 May 25; 4(5): 2892–2900, Text.

mPEG-SH (Surface PEGylation of Gold Nanoparticles) - On Sensitivity of Molecular Specific Photoacoustic Imaging Using Plasmonic Gold Nanoparticles, Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6338-40, Text.

mPEG-SH (Surface PEGylation) - Gold nanorod mediated plasmonic photothermal therapy: A tool to enhance macromolecular delivery, Int J Pharm. 2011 August 30; 415(1-2): 315–318, Text.

mPEG-SH (Surface PEGylation of Gold Nanorods) - Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood , J. Biomed. Opt. 17(10), 106016 (Oct 17, 2012), Text.

mPEG-SH (Surface PEGylation of Gold Nanorods) - Conjugation of antibodies to gold nanorods through Fc portion: synthesis and molecular specific imaging, Bioconjug Chem. 2013 June 19; 24(6): 878–888, Text.

mPEG-SH (PEGylation of Metallic Nanoparticles) - Plasmon-Resonant Gold Nanoparticles with Variable Morphology as Optical Labels and Drug Carriers for Cytological Research, Proc. of SPIE-OSA/ Vol. 8801 880102-2, Text.

mPEG-SH (PEGylation of Nanorods) - Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors, Nuclear Medicine and Biology 41 (2014) 282–289, Text.

mPEG-SH (PEGylation of Nanoparticles) - Detecting protein adsorption and binding using magnetic nanoparticle probes, Sensors and Actuators B 160 (2011) 650– 655, Text.

HS-PEG-COOH (Surface PEGylation of Gold Nanoparticles) - Capping and in vivo toxicity studies of gold nanoparticles. Adv. Nat. Sci.: Nanosci. Nanotechnol. 3 (2012) 015002 (5pp), Text.

HS-PEG-NH2 (Surface PEGylation of Gold Nanoparticles) - Gold Nanorods: Controlling Their Surface Chemistry and Complete Detoxification by a Two-Step Place Exchange. Angewandte Chemie 2013, 125 (7): 1988-1992. Text, experimental details in SI.

mPEG-Amine (Carboxyl PEGylation of Nanoparticles) - Upconverting Luminescent Nanomaterials: Application to In Vivo Bioimaging, Chem Commun (Camb). 2009 Jul 28;(28):4188-90, Text, experimental details in SI.

mPEG-Amine (Carboxyl PEGylation of Nanoparticles) - Design and demonstration of a small-animal upconversion imager, Opt Express. 2008 December 22; 16(26): 21731–21737, Text.

mPEG-Amine (Carboxyl PEGylation) - Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations, Pharm Res (2011) 28:1112–1120, Text.

mPEG-Amine (Carboxyl PEGylation) - Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging, J Phys Condens Matter. 2010; 22(19): 194121, Text.

mPEG-Amine (Carboxyl PEGylation of Nanoparticles) - Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues, Mol Pharm. 2013 June 3; 10(6): 2176–2182, Text.

mPEG-Amine (Carboxyl PEGylation of Nanoparticles) - Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo, J Control Release. 2013 April 10; 167(1): 76–84, Text.

mPEG-Amine (Carboxyl PEGylation of Nanoparticles) - Nanoparticle diffusion in respiratory mucus from humans without lung disease, Biomaterials. 2013 April ; 34(13): 3439–3446, Text.

mPEG-Amine (PEGylation of Carboxylated Nanoparticles) - Immobilization of Pseudorabies Virus in Porcine Tracheal Respiratory Mucus Revealed by Single Particle Tracking, PLoS ONE 7(12): e51054, Text.

mPEG-Acid (PEGylation of Aminated Microparticles) - Interfacial polymer phase segregation and self-assembly of square colloidal crystals, Soft Matter, 2012, 8, 6684, Text.

mPEG-Silane (Surface PEGylation of Nanoparticles) - Measurement of enzyme kinetics and inhibitor constants using enthalpy arrays, Anal Biochem. 2009 May 15; 388(2): 204–212, Text.

mPEG-Silane (Surface PEGylation of Glass) - Rapid mixing of sub-microliter drops by magnetic micro-stirring, Lab Chip. 2011 October 7; 11(19): 3313–3319, Text.

mPEG-Silane (Surface PEGylation of Silicon) - Fluorinated Silicon Surfaces under Mixed Surfactants: Resistance to Nonspecific Protein Adsorption for Biosensing, Langmuir. 2009 Nov 3;25(21):12404-7, Text.

mPEG-Silane (Hydroxyl PEGylation of Nanoparticles) - Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands, J. Mater. Chem., 2011, 21, 3037, Text.

mPEG-Silane (Surface PEGylation of Glass) - MAP65/Ase1 promote microtubule flexibility, Mol. Biol. Cell, June 15, 2013 vol. 24 no. 12 1964-1973, Text.

mPEG-Silane: (Surface PEGylation of Silica) - Micropatterning neuronal networks, Analyst, 2014, 139, 3256-3264, Text.

mPEG-NHS (Amine PEGylation of Chips) - Fabricating Nanoscale DNA Patterns with Gold Nanowires, Anal Chem. 2010 April 15; 82(8): 3365–3370, Text.

mPEG-SG (PEGylation of Aminated Surfaces) - Experimental and Numerical Studies of Tethered DNA Shear Dynamics in the Flow-Gradient Plane, Macromolecules, 2009, 42 (22), pp 9170–9182, Text.

mPEG-Azide (Clickable PEGylation of Membrane) - Effect of End Groups and Grafting on the CO2 Separation Performance of Poly(ethylene glycol) Based Membranes , Macromolecules, 2011, 44 (19), pp 7727–7736, Text.

mPEG-Azide (Clickable PEGylation of Nanoparticles) - Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe3O4 Nanoparticles, Macromol. Rapid Commun. 2010, 31, 1608–1615, Text.

mPEG-Aldehyde (Reversible Hydrazide PEGylation of Micelles) - The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabineloaded micelles on drug resistance caused by RRM1 overexpression, Biomaterials. 2013 March; 34(9): 2327–2339, Text.

Biotin PEGylation and Biotinylation

Biotin-PEG-NHS (Biotinylation and Amine PEGylation of Chips) - Multi-modal particle manipulator to enhance bead-based bioassays, Ultrasonics. 2010 Feb;50(2):235-9, Text.

Biotin-PEG-NHS (Biotinylation of Aminated Microbeads) - Flexible Acoustic Particle Manipulation Device with Integrated Optical Waveguide for Enhanced Microbead Assays, Anal Sci. 2009; 25(2):285-91, Text.

Biotin-PEG-SCM (Biotinylation of Aminated Surface) - Experimental and Numerical Studies of Tethered DNA Shear Dynamics in the Flow-Gradient Plane, Macromolecules, 2009, 42 (22), pp 9170–9182, Text.

Biotin-PEG-SCM (Amine PEGylation of Nucleic Acid) - Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing, J. Am. Chem. Soc., 2012, 134 (17), pp 7423–7430, Text.

Biotin-PEG-Silane (Biotinylation of Hydroxylated Surface) - MAP65/Ase1 promote microtubule flexibility, Mol. Biol. Cell, June 15, 2013 vol. 24 no. 12 1964-1973, Text.

PEGylation Crosslinkers – Drug Delivery, Molecular Imaging, Biophysics

OPSS-PEG-NHS (Crosslinking Antibody (Amine PEGylation) to Nanoparticles (Thiol PEGylation) ) - Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy, Breast Cancer Res Treat, 2010; 120(3):547-55, Text.

OPSS-PEG-NHS (Crosslinking Antibody (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Evaluation of Immunotargeted Gold Nanoshells as Rapid Diagnostic Imaging Agents for HER2-Overexpressing Breast Cancer Cells: A Time-based Analysis, Nanobiotechnology, vol. 4, no. 1–4, pp. 1–8, 2008, Text.

OPSS-PEG-NHS (Crosslinking Antibody (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Enhanced multi-spectral imaging of live breast cancer cells using immunotargeted gold nanoshells and two-photon excitation microscopy, Nanotechnology 19 (2008) 315102, Text.

OPSS-PEG-NHS (Crosslinking Proteins (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles, Cancer Lett. 2010, 1;292(1):91-7, Text.

OPSS-PEG-NHS (Crosslinking Peptide (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Biological evaluation of RGDfK-gold nanorod conjugates for prostate cancer treatment. Journal of Drug Targeting, 2011; 19(10): 915–924, Text.

OPSS-PEG-NHS (Crosslinking Antibody (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells, Journal of Controlled Release, 162 (2012) 303–309, Text.

OPSS-PEG-NHS (Crosslinking Proteins (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Gold nanorods for target selective SPECT/CT imaging and photothermal therapy in vivo. Quant Imaging Med Surg, 2012;2:1-11, Text,

OPSS-PEG-NHS (Crosslinking Proteins (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging, Nanotechnology. 2012 February 24; 23(7): 075102, Text,

OPSS-PEG-NHS (Crosslinking Antibody (Amine PEGylation) to Nanoparticles (Thiol PEGylation)) - Multiplexed Dot Immunoassay Using Ag Nanocubes, Au/Ag Alloy Nanoparticles, and Au/Ag Nanocages, Nano Res. 2012, 5(2): 124–134, Text,

OPSS-PEG-NHS (Crosslinking Peptides (Amine PEGylation) to Surface (Thiol PEGylation)) - Peptide-Surface Adsorption Free Energy Comparing Solution Conditions Ranging from Low-to-Medium Salt Concentrations, Chemphyschem. 2012, 13(17): 3782–3785, Text,

OPSS-PEG-NHS (Crosslinking siRNA and Oligonucleotide (Thiol PEGylation) to Monosaccharide and Polysaccharide (Amine PEGylation)) - Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation, Bioconjugate Chem. 2010, 21, 2119–2127, Text,

MAL-PEG-NHS (Crosslinking of Peptide (Thiol PEGylation) to Polymer (Amine PEGylation) - Virus-Inspired Approach to Nonviral Gene Delivery Vehicles, Biomacromolecules. 2009, 10;10(8):2189-93, Text.

MAL-PEG-NHS (Crosslinker Proteins (Thiol PEGylation) to Small Molecules (Amine PEGylation)) - Synthesis and characterization of scVEGF-PEG-[68Ga]NOTA and scVEGF-PEG-[68Ga]DOTA PET tracers, J. Label Compd. Radiopharm, 2011, 54 685–692, Text.

MAL-PEG-SCM (Crosslinking of Proteins (Amine PEGylation) to Thiolated Surface) - Structure and Biosynthesis of Two Exopolysaccharides Produced by Lactobacillus johnsonii FI9785, J. Biol. Chem. 2013, 288:31938-31951, Text.

MAL-PEG-SCM (Crosslinking of Peptides (Amine PEGylation) to Thiolated Nanoparticles) - Cancer-Targeted Optical Imaging with Fluorescent Zinc Oxide Nanowires, Nano Lett. 2011 September 14; 11(9): 3744–3750, Text.

MAL-PEG-SCM (Crosslinking of Peptides (Amine PEGylation) to Thiolated Nanoparticles) - Evolution of zinc oxide nanostructures through kinetics control, J. Mater. Chem., 2011, 21, 9000-9008, Text.

MAL-PEG-SCM (Crosslinking of Peptides (Amine PEGylation) to Thiolated Cholesterol) - Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized d-Peptide Inhibitors of HIV-1 Entry, Bioconjugate Chem., 2012, 23 (6), pp 1252–1258, Text.

MAL-PEG-SCM (Crosslinking of Peptides (Thiol PEGylation) to Nanoparticles) - Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy, Photochem. Photobiol. Sci., 2011, 10, 832-841, Text.

MAL-PEG-SCM (Crosslinking of Antibodies (Thiol PEGylation) to Graphene) - Tumor Vasculature Targeting and Imaging in Living Mice with Reduced Graphene Oxide, Biomaterials. 2013 April ; 34(12): 3002–3009, Text.

MAL-PEG-SCM (Crosslinking of Antibodies (Thiol PEGylation) to Graphene) - In Vivo Targeting and Positron Emission Tomography Imaging of Tumor Vasculature with 66Ga-Labeled Nano-Graphene, Biomaterials. 2012 June; 33(16): 4147–4156, Text.

MAL-PEG-SCM (Crosslinking Proteins to Peptide) - Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice, Hepatology, 54: 586–596, Text.

MAL-PEG-Amine (Crosslinking Antibody (Site-Specific Thiol PEGylation) to Dendrimer (Carboxyl PEGylation)) - Transbuccal Delivery of CNS Therapeutic Nanoparticles: Synthesis, Characterization, and In Vitro Permeation Studies, ACS Chem. Neurosci., 2011, 2 (11), pp 676–683, Text.

MAL-PEG-NH2 (Crosslinking siRNA (Thiol PEGylation) to Chemotherapeutics (Carboxyl PEGylation)) - Methods and Compositions for Improved Therapeutic Effects with siRNA, Patent US20080311040 A1, Text.

Hydrazide-PEG-OPSS (Crosslinking of Antibodies (Carbonyl PEGylation) to Nanoparticles (Thiol PEGylation)) - Multiwavelength Photoacoustic Imaging and Plasmon Resonance Coupling of Gold Nanoparticles for Selective Detection of Cancer, Nano Lett. 2009 August ; 9(8): 2825–283, Text.

Hydrazide-PEG-OPSS (Crosslinking of Antibodies (Site-Specific Carbonyl PEGylation) to Nanoparticles (Thiol PEGylation)) - EGFR-Targeted Hybrid Plasmonic Magnetic Nanoparticles Synergistically Induce Autophagy and Apoptosis in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2011, 6(11): e25507, Text.

HS-PEG-COOH (Crosslinking Proteins (Amine PEGylation) to Gold Chips) - Single-Molecule Force Spectroscopy of the Aplysia Cell Adhesion Molecule Reveals Two Homophilic Bonds. Biophysical Journal 2012; 103: 649–657, Text.

HS-PEG-COOH (Crosslinking Antibodies to Gold Nanoparticles) - The Effect of Nanoparticle Size on Cellular Binding Probability, Journal of Atomic, Molecular, and Optical Physics. 2012 (2012), Article ID 404536, 7 pages, Text.

HS-PEG-COOH (Crosslinking Proteins to Gold Nanorods) - A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods, Int J Nanomedicine. 2012;7: 449–455, Text.

HS-PEG-COOH (Crosslinking Antibodies to Gold Nanoparticles) - Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study, Int J Nanomedicine. 2011; 6: 2859–2864, Text.

HS-PEG-COOH (Crosslinking Antibodies to Gold Nanoparticles) - Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles, Int J Nanomedicine. 2012; 7: 4707–4713, Text.

HS-PEG-COOH (Crosslinking Proteins to Chips) - Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding, Lab Chip, 2010, 10, 2655–2658, Text.

Thiol-PEG-Acid (Crosslinking of Enzymes to Gold Surface) - High-Resolution Single-Molecule Recognition Imaging of the Molecular Details of Ricin−Aptamer Interaction, J. Phys. Chem. B 2012, 116, 5316−5322, Text.

Thiol-PEG-Acid (Crosslinking Proteins to Gold Nanoparticles) - Transport of nanoparticles through the blood–brain barrier for imaging and therapeutic applications, Nanoscale, 2014, 6, 2146, Text.

Thiol-PEG-Acid (Crosslinking Antibodies to Gold Nanoparticles) - New optical method for enhanced detection of colon cancer by capsule endoscopy, Nanoscale, 2013, 5, 9806, Text.

Thiol-PEG-Amine (Crosslinking Antibody to Nanoparticles) - Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing, ACS Nano, 2012, 6 (4), pp 3506–3513, Text.

Acrylate-PEG-SCM (Protein Conjugation (Amine PEGylation) to PEG Hydrogel) - Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323–3328, Text.

Acrylate-PEG-NHS (Crosslinking Proteins to PEG Hydrogels) - Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration, Biomaterials, 2013 (34): 7381-7388, Text.

Acrylate-PEG-NHS (Crosslinking Proteins to PEG Hydrogels) - Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration, Acta Biomaterialia 10 (2014) 1102–1111, Text.

4-Arm PEG-Acrylate (Crosslinking Thiolated siRNA) - Methods and Compositions for Improved Therapeutic Effects with siRNA, Patent US20080311040 A1, Text.

NHS-PEG-NHS (Crosslinking Nucleotide to Silicon Surface) - Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers. Nucleic Acids Research, 2013, 1–12, Text.

NHS-PEG-NHS (Crosslinking siRNA (Amine PEGylation) to Antibody (Amine PEGylation)) - Methods and Compositions for Improved Therapeutic Effects with siRNA, Patent US20080311040 A1, Text.

PEG Hydrogel - Regenerative Medicine, Tissue Engineering, Drug Delivery

Thiol-PEG-Thiol (PEG Hydrogels) - Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration, Biomaterials, 2013 (34): 7381-7388, Text.

Maleimide-PEG-Maleimide (Crosslinking Proteins and Hydrogels) - Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries, Front. Chem. 2:23. doi: 10.3389/fchem.2014.00023, Text.

mPEG-Acrylate (Acryl PEGylation) - Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene , J. Am. Chem. Soc., 2012, 134 (17), pp 7423–7430, Text.

Acrylate-PEG-Acrylate (PEG Hydrogel) - Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323–3328, Text.

Acrylate-PEG-Acrylate (PEG Hydrogel) - Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing, J. Am. Chem. Soc., 2012, 134 (17), pp 7423–7430, Text.

Acrylate-PEG-NHS (PEG-PCL Hydrogel and Conjugation of Proteins) - Shape Memory RGD-Containing Networks: Synthesis, Characterization, and Application in Cell Culture, Macromol. Symp. 2011, 309/310, 162–172, Text.

Azide-PEG-Azide (Click Chemistry and PEG-Hyaluronan Hydrogel) - Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors, Cell Reports 7, 1926–1939, June 26, 2014, Text.

4-Arm PEG-Acrylate (Acryl PEGylation and Hydrogel) - Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture, Biomaterials, Volume 32, Issue 10, April 2011, Pages 2524–2531, Text.

4-Arm PEG-SH (PEG Hydrogel) - Thiolated hyaluronan-based hydrogels crosslinked using oxidized glutathione: An injectable matrix designed for ophthalmic applications, Acta Biomaterialia 10 (2014) 94–103, Text.

4-Arm PEG Alkyne (Click Chemistry) - Biodegradable poly(ethylene glycol)–peptide hydrogels with well-defined structure and properties for cell delivery, Biomaterials. 2009 Mar;30(8):1453-61, Text.

4-Arm PEG-Azide and 4-Arm PEG-Alkyne (Clickable PEG Hydrogels) - Ultralow Protein Adsorbing Coatings from Clickable PEG Nanogel Solutions: Benefits of Attachment under Salt-Induced Phase Separation Conditions and Comparison with PEG/Albumin Nanogel Coatings. Langmuir 2013, 29, 4128−4139, Text.

4-Arm PEG-Alkyne (Click PEG Hydrogel) - Photoinitiated Alkyne−Azide Click and Radical Cross-Linking Reactions for the Patterning of PEG Hydrogels, Biomacromolecules 2012, 13, 889−895, Text.

4-Arm PEG-Azide (Azide-Alkyne Click PEG Hydrogel) - Supramolecular polymer gels with potential model-network structure, Polym. Chem., 2014, 5, 3018-3029, Text.

8-Arm PEG-Vinylsulfone and 8-Arm PEG-Amine (Crosslinked PEG Microspheres and Hydrogels) - Long term culture of HL-1 cardiomyocytes in modular poly(ethylene glycol) microsphere-based scaffolds crosslinked in the phase separated state. Acta Biomater. 2012, 8(1): 31–40, Text.

8-Arm PEG-Vinyl Sulfone (PEG Hydrogel and Protein Conjugation) - Nanogel surface coatings for improved single-molecule imaging substrates, J R Soc Interface. 2011 October 7; 8(63): 1400–1408, Text.

8-Arm PEG-Acrylate (PEG Hydrogels) - Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration, Biomaterials, 2013 (34): 7381-7388, Text.

8-Arm PEG-Maleimide (PEG Hydrogels and Thiol-Reactive Protein Conjugation) - Tuning the thermosensitive properties of hybrid collagen peptide–polymer hydrogels, Chem. Commun., 2014, 50, 8174-8176, Text. Experimental details in SI.

Self-Assembling – PEGylated Liposome, Micelle, Monolayer

DSPE-PEG-Maleimide (Thiol PEGylation of Enzymes) - Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting, ACS Nano, 2012, 6 (4), pp 3491–3498, Text.

DSPE-PEG-Maleimide (Thiol PEGylation of Peptides) - APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes, Journal of Controlled Release 154 (2011) 298–305, Text.

DSPE-PEG-MAL (Self-assembly and Thiol PEGylation) - Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancer, Nanotechnology 22 (2011) 455101, Text.

DSPE-PEG-MAL (Self-assembly and Thiol PEGylation) - Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy, 2013 Nanotechnology 24 375104, Text.

DSPE-PEG-MAL (PEGylated Micelles and Thiol PEGylation) - Aggregation-enhanced fluorescence in PEGylated phospholipid nanomicelles for in vivo imaging, Biomaterials 32 (2011) 5880e5888, Text.

mPEG-DSPE (Micelle Encapsulation of Nanoparticles) - Using 915 nm Laser Excited Tm3þ/ Er3þ/Ho3þ-Doped NaYbF4 Upconversion Nanoparticles for in Vitro and Deeper in Vivo Bioimaging without Overheating Irradiation, ACS Nano, 2011, 5 (5), pp 3744–3757, Text.

mPEG-DSPE (Surface PEGylation of Lipophilic Nanoparticles) - ‘Green’-synthesized near-infrared PbS quantum dots with silica–PEG dual-layer coating: ultrastable and biocompatible optical probes for in vivo animal imaging, 2012 Nanotechnology 23 245701, Text.

mPEG-DSPE (Micelle Encapsulation of Quantum Dots) - Biocompatible and Photostable AIE Dots with Red Emission for In Vivo Two-Photon Bioimaging. Sci. Rep. 2014, 4, 4279, Text.

mPEG-DSPE (PEGylated Phospholipid Micelle Encapsulation of Nanoparticles) - Optimization of Optical Excitation of Upconversion Nanoparticles for Rapid Microscopy and Deeper Tissue Imaging with Higher Quantum Yield. Theranostics 2013, 3 (5):306-316, Text.

mPEG-C18 (Micelle Formulation and Coassembly with Lipidated Nucleoside) - Lysosomal Delivery of a Lipophilic Gemcitabine Prodrug Using Novel Acid-Sensitive Micelles Improved Its Antitumor Activity, Bioconjugate Chem., 2012, 23 (5), pp 966–980, Text.

C18-PEG-NHS (Micelle Encapsulation and Amine PEGylation of Peptide) - Octreotide-Modified N-Octyl-O, N-Carboxymethyl Chitosan Micelles as Potential Carriers for Targeted Antitumor Drug Delivery. J Pharm Sci. 2012 Feb;101(2):627-40, Text.

C18-PEG6-Azide (PEGylated Micelles and Click PEGylation of Proteins) - Evaluation of Nanolipoprotein Particles (NLPs) as an In Vivo Delivery Platform, PLoS ONE 9(3): e93342. doi:10.1371/journal.pone.0093342, Text.

mPEG-COOH (PEG Surfactant, Nanoparticle Encapsulation and Peptide Bioconjugation) - Highly emissive PEG-encapsulated conjugated polymer nanoparticles, Nanoscale, 2012, 4, 5694, Text.

mPEG-Hydrazide (Reversible PEGylation of Micelles) - Lysosomal Delivery of a Lipophilic Gemcitabine Prodrug Using Novel Acid-Sensitive Micelles Improved Its Antitumor Activity, Bioconjugate Chem., 2012, 23 (5), pp 966–980, Text.

Small Molecule PEGylation and Miscellaneous

mPEG-Amine (Carboxyl PEGylation) - A Photoinducible 1,3-Dipolar Cycloaddition Reaction for Rapid, Selective Modification of Tetrazole-Containing Proteins, Angew Chem Int Ed Engl. 2008;47(15):2832-5, Text, experimental details in SI.

Fmoc-NH-PEG-NHS (Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery, React Funct Polym. 2011 March 1; 71(3): 315–323) - &&, Text.

Fmoc-NH-PEG-NHS (Crosslinking Biotin to Small Molecule Drug) - A prodrug nanoassembly entrapping drugs as a tumor-targeted delivery system, Chem. Commun., 2013, 49, 801-803, Text.

mPEG-OH (Conjugation with Photosensitive Copolymers) - Soft Nanoparticles Assembled from Linear Poly(ethylene glycol) and Linear Brush Polydimethylsiloxane Diblock Copolymers, J. Polym. Sci. A Polym. Chem., 52: 1251–1262, Text.

mPEG-Amine (PEGylated PEI Copolymer for Gene Delivery) - Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA, Int J Pharm. 2012 May 1; 427(1): 123–133, Text.

4-Arm PEG-OH and 4-Arm PEG-PLA (Diblock Copolymer and Self-Assembly) - Biodegradable Polymersomes from Four-Arm PEG-b-PDLLA for Encapsulating Hemoglobin, J. APPL. POLYM. SCI. 2014, DOI: 10.1002/APP.40433, Text.

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