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Reactive PEG reagents are used to derivatize, functionalize, conjugate or crosslink a variety of substrate molecules, particles and surfaces. Listed below are selected literature examples of successful PEGylation using Creative PEGWorks' PEG products.

 

PEGYLATION LITERATURE:

Biologics PEGylation - Proteins, Antibodies, Peptides, Nucleic Acids etc.

Amine PEGylation (Biotin-PEG-SCM) - Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing, J. Am. Chem. Soc., 2012, 134 (17), pp 7423–7430. Text.
Thiol PEGylation (mPEG-Maleimide) - Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel, Biochemistry, 2012, 51 (31), pp 6195–6206, Text.
Amine PEGylation (Thiol-PEG-Acid) - High-Resolution Single-Molecule Recognition Imaging of the Molecular Details of Ricin−Aptamer Interaction, J. Phys. Chem. B 2012, 116, 5316−5322, Text.
Thiol PEGylation (OPSS-PEG-NHS) - Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation, Bioconjugate Chem. 2010, 21, 2119–2127, Text.
PEG Crosslinker (Fmoc-NH-PEG-NHS) - Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery, React Funct Polym. 2011 March 1; 71(3): 315–323, Text.
Thiol PEGylation (MAL-PEG-NHS) - Virus-Inspired Approach to Nonviral Gene Delivery Vehicles, Biomacromolecules, 2009, 10, 2189–2193, Text.
Amine PEGylation (HS-PEG-COOH) - Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study, Int J Nanomedicine. 2011; 6 : 2859–2864, Text.
Thiol PEGylation (mPEG-Maleimide) - In vitro folding of KvAP, a voltage gated K+ channel, Biochemistry. 2011 December 6; 50(48): 10442–10450, Text.
Thiol PEGylation (mPEG-MAL) - The holin of bacteriophage lambda forms rings with large diameter, Molecular Microbiology, 09/2008; 69(4):784-793, Text.
PEG Crosslinker (OPSS-PEG-NHS) - Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy, Breast Cancer Res Treat. 2010; 120(3):547-55, Text.
Cysteine PEGylation (mPEG-Maleimide) - Structure of the lethal phage pinhole, Proc Natl Acad Sci USA. 2009;106(45):18966-71, Text.
Amine PEGylation (Acrylate-PEG-SCM) - Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323–3328, Text
Thiol PEGylation (mPEG-Maleimide) - Thiol protection in membrane protein purifications: a study with phage holins, Anal Biochem, 2009, 390(2):221-3. Text.
Amine PEGylation (OPSS-PEG-NHS) - Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells, Journal of Controlled Release 162 (2012) 303–309, Text.
Nanoparticle PEGylation - Drug Delivery, Hydrogel, Tissue Scaffold Engineering, Regenerative Medicine
Thiol PEGylation (mPEG-Thiol) - Spatiotemporal Temperature Distribution and Cancer Cell Death in Response to Extracellular Hyperthermia Induced by Gold Nanorods, ACS Nano. 2010 May 25; 4(5): 2892–2900, Text.
Acryl PEGylation (4-Arm PEG-Acrylate) - Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture, Biomaterials, Volume 32, Issue 10, April 2011, Pages 2524–2531. Text.
Thiol PEGylation (Thiol-PEG-Amine) - Orthogonal Amplification of Nanoparticles for Improved Diagnostic Sensing , ACS Nano, 2012, 6 (4), pp 3506–3513, Text.
PEG Crosslinker (MAL-PEG-NHS) - Cancer-Targeted Optical Imaging with Fluorescent Zinc Oxide Nanowires, Nano Lett. 2011 September 14; 11(9): 3744–3750, Text.
Thiol PEGylation (8-Arm PEG-Vinyl Sulfone) - Nanogel surface coatings for improved single-molecule imaging substrates , J R Soc Interface. 2011 October 7; 8(63): 1400–1408. Text.
Thiol PEGylation (mPEG-Thiol) - Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood , J. Biomed. Opt. 17(10), 106016 (Oct 17, 2012). Text.
PEG Crosslinker (MAL-PEG-SCM) - Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized d-Peptide Inhibitors of HIV-1 Entry , Bioconjugate Chem., 2012, 23 (6), pp 1252–1258, Text.
Thiol PEGylation (OPSS-PEG-NHS) - Controlled release of Rituximab from gold nanoparticles for phototherapy of malignant cells, Journal of Controlled Release 162 (2012) 303–309, Text.
Silica PEGylation (mPEG-Silane) - Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands, J. Mater. Chem., 2011, 21, 3037, Text.
Carboxyl PEGylation (mPEG-Amine) - Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations, Pharm Res (2011) 28:1112–1120, Text.
Gold PEGylation (mPEG-Thiol) - Multiwavelength Photoacoustic Imaging and Plasmon Resonance Coupling of Gold Nanoparticles for Selective Detection of Cancer, Nano Lett. 2009 August ; 9(8): 2825–283, Text.
Click PEGylation (mPEG-Azide) - Biomimetic Mussel Adhesive Inspired Clickable Anchors Applied to the Functionalization of Fe3O4 Nanoparticles, Macromol. Rapid Commun. 2010, 31, 1608–1615, Text.
PEG Crosslinking (OPSS-PEG-NHS) - Gold nanorods for target selective SPECT/CT imaging and photothermal therapy in vivo. Quant Imaging Med Surg 2012;2:1-11, Text.
Thiol PEGylation (OPSS-PEG-NHS) - Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging, Nanotechnology. 2012 February 24; 23(7): 075102, Text.
Carboxyl PEGylation (mPEG-Amine) - Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging, J Phys Condens Matter. 2010 ; 22(19): 194121, Text.
Carboxyl PEGylation (mPEG-Amine) - Design and demonstration of a small-animal up-conversion imager, Opt Express. 2008 December 22; 16(26): 21731–21737, Text.
Thiol PEGylation (HS-PEG-COOH) - Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles, Int J Nanomedicine. 2012; 7 : 4707–4713, Text.
Amine PEGylation (MAL-PEG-SCM) - Evolution of zinc oxide nanostructures through kinetics control, J. Mater. Chem., 2011, 21, 9000-9008, Text.
PEG Crosslinker (HS-PEG-COOH) - A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods, Int J Nanomedicine. 2012; 7 : 449–455, Text.
Thiol PEGylation (mPEG-Thiol) - Gold nanorod mediated plasmonic photothermal therapy: A tool to enhance macromolecular delivery, Int J Pharm. 2011 August 30; 415(1-2): 315–318, Text.
PEG Crosslinker (OPSS-PEG-NHS) - Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles, Cancer Lett. 2010, 1;292(1):91-7, Text.
Thiol PEGylation (mPEG-MAL) - The holin of bacteriophage lambda forms rings with large diameter, Molecular Microbiology, 09/2008; 69(4):784-793, Text.
Gold PEGylation (mPEG-Thiol) - On Sensitivity of Molecular Specific Photoacoustic Imaging Using Plasmonic Gold Nanoparticles, Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6338-40, Text.
PEG Crosslinker (OPSS-PEG-NHS) - Evaluation of Immunotargeted Gold Nanoshells as Rapid Diagnostic Imaging Agents for HER2-Overexpressing Breast Cancer Cells: A Time-based Analysis, Nanobiotechnology, vol. 4, no. 1–4, pp. 1–8, 2008, Text.
Carboxyl PEGylation (mPEG-Amine) - Upconverting Luminescent Nanomaterials: Application to In Vivo Bioimaging, Chem Commun (Camb). 2009 Jul 28;(28):4188-90, Text, experimental details in SI.
PEG Crosslinker (OPSS-PEG-NHS) - Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy, Breast Cancer Res Treat. 2010; 120(3):547-55, Text.

Click chemistry (PEG acetylene, PEG azide) - Biodegradable poly(ethylene glycol)–peptide hydrogels with well-defined structure and properties for cell delivery, Biomaterials. 2009 Mar;30(8):1453-61, Text.

PEG Hydrogel (Acrylate-PEG-Acrylate), Peptide PEGylation (Acrylate-PEG-SCM) - Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323–3328, Text.
Cysteine PEGylation (mPEG-Maleimide) - Structure of the lethal phage pinhole, Proc Natl Acad Sci USA. 2009;106(45):18966-71, Text.
PEG Crosslinker (OPSS-PEG-NHS) - Enhanced multi-spectral imaging of live breast cancer cells using immunotargeted gold nanoshells and two-photon excitation microscopy, Nanotechnology 19 (2008) 315102, Text.
Acryl PEGylation (mPEG-Acrylate) - Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing, J. Am. Chem. Soc., 2012, 134 (17), pp 7423–7430. Text.

Surface, Membrane, Dendrimer PEGylation

Click PEGylation (mPEG-Azide) - Effect of End Groups and Grafting on the CO2 Separation Performance of Poly(ethylene glycol) Based Membranes , Macromolecules, 2011, 44 (19), pp 7727–7736, Text.
Thiol PEGylation (Thiol-PEG-Acid) - High-Resolution Single-Molecule Recognition Imaging of the Molecular Details of Ricin−Aptamer Interaction, J. Phys. Chem. B 2012, 116, 5316−5322, Text.
PEG Crosslinker (Fmoc-NH-PEG-NHS) - Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery, React Funct Polym. 2011 March 1; 71(3): 315–323, Text.
Metal PEGylation (mPEG-Silane) - Measurement of enzyme kinetics and inhibitor constants using enthalpy arrays, Anal Biochem. 2009 May 15; 388(2): 204–212, Text.
Biotin PEGylation (Biotin-PEG-NHS) - Multi-modal particle manipulator to enhance bead-based bioassays, Ultrasonics 2010 Feb;50(2):235-9, Text.
Glass PEGylation (mPEG-Silane) - Rapid mixing of sub-microliter drops by magnetic micro-stirring, Lab Chip. 2011 October 7; 11(19): 3313–3319, Text.
Amine PEGylation (mPEG-NHS) - Fabricating Nanoscale DNA Patterns with Gold Nanowires, Anal Chem. 2010 April 15; 82(8): 3365–3370, Text.
Amine PEGylation and Biotin PEGylation (mPEG-SG, Biotin-PEG-NHS) - Experimental and Numerical Studies of Tethered DNA Shear Dynamics in the Flow-Gradient Plane, Macromolecules, 2009, 42 (22), pp 9170–9182, Text.
Silicon PEGylation (mPEG-Silane) - Fluorinated Silicon Surfaces under Mixed Surfactants: Resistance to Nonspecific Protein Adsorption for Biosensing, Langmuir. 2009 Nov 3;25(21):12404-7, Text.
Amine PEGylation (Biotin-PEG-NHS) - Flexible Acoustic Particle Manipulation Device with Integrated Optical Waveguide for Enhanced Microbead Assays, Anal Sci. 2009; 25(2):285-91, Text.
Carboxyl PEGylation (MAL-PEG-Amine) - Transbuccal Delivery of CNS Therapeutic Nanoparticles: Synthesis, Characterization, and In Vitro Permeation Studies , ACS Chem. Neurosci., 2011, 2 (11), pp 676–683, Text.

Self-assemblies, Liposomes, Micelles, Monolayers etc.

Lipid PEGylation (DSPE-PEG-Maleimide) - Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting , ACS Nano, 2012, 6 (4), pp 3491–3498, Text.
Thiol PEGylation (DSPE-PEG-Maleimide) - APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes, Journal of Controlled Release 154 (2011) 298–305, Text.
Lipid Assemply (mPEG-DSPE) - Using 915 nm Laser Excited Tm3þ/ Er3þ/Ho3þ-Doped NaYbF4 Upconversion Nanopartic les for in Vitro and Deeper in Vivo Bioimaging without Overheating Irradiation, ACS Nano, 2011, 5 (5), pp 3744–3757, Text.

Amphiphatic PEGylation (mPEG-Amine) - Lysosomal Delivery of a Lipophilic Gemcitabine Prodrug Using Novel Acid-Sensitive Micelles Improved Its Antitumor Activity, Bioconjugate Chem., 2012, 23 (5), pp 966–980, Text.

Lipid PEGylation (DSPE-PEG-MAL) - Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancer, Nanotechnology 22 (2011) 455101, Text.
Carboxyl PEGylation (mPEG-Hydrazide) - Lysosomal Delivery of a Lipophilic Gemcitabine Prodrug Using Novel Acid-Sensitive Micelles Improved Its Antitumor Activity, Bioconjugate Chem., 2012, 23 (5), pp 966–980, Text.

Small molecule PEGylation and miscellaneous.

Amine PEGylation (Acrylate-PEG-SCM) - Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323–3328, Text
Carboxyl PEGylation (mPEG-Amine) - A Photoinducible 1,3-Dipolar Cycloaddition Reaction for Rapid, Selective Modification of Tetrazole-Containing Proteins, Angew Chem Int Ed Engl. 2008;47(15):2832-5. Text, experimental details in SI.
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