Acid and NHS ester functionalized PEG-PLA is a useful reagent to prepare core-shell
nanoparticles with an amine-reactive maleimide for conjugation with
peptide or proteins bearing free amine. PEG-PLA is an
amphiphilic AB diblock copolymer consisting of a hydrophilic block
polyethylene glycol (PEG) or polyethylene oxide (PEO) and a hydrophobic
block polylactic acid or polylactide (PLA). The PEG polymer is capped a
methyl ether group, and the hydrophobic block terminates with a hydroxyl
group. PEGylated copolymers with biodegradable and biocompatible
polyester segments can be used to prepare core-shell micelles,
nanoparticles and microspheres.
References: 1) Biodegradable long-circulating polymeric nanospheres. Science 1994;363:1600â€“3, Text.
2) Preparation, characterization and properties of polylactide (PLA) - poly(ethylene glycol) (PEG)
copolymers: a potential drug carrier. J Appl Polym Sci 1990;39: