Catalog No. : HA-341
Product Name : Hyaluronate NHS ester, MW 10k
Description :

Hyaluronic Acid is functionalized with NHS ester groups. Purity: >95% powder. Degree of substitution: 5 mol % substitution. HA-NHS with lower or higher N-hydroxyl succinimidyl ester substitution ratio (e.g. 1% and 10%) may be offered through custom synthesis service. Also sulfo-NHS ester could also be made by custom synthesis.

The azide substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with azide groups. You may calculate the number of azide by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio to get the number of azide in each HA polymer.

Literature: 1. A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer, Journal of Controlled Release, 2017, doi 10.1016/j.jconrel.2017.08.016, Text.

2. Hyaluronic acid based scaffolds for tissue engineering—A review, Carbohydrate Polymers 2013, 92(2):1262– 1279;

3. An insight on hyaluronic acid in drug targeting and drug delivery, J Drug Target, 2008, 16(2):91-107

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