Catalog No. : HA-603
Product Name : Hyaluronate Biotin, MW 750k
Description :

Hyaluronic Acid is labeled with biotin. Purity: >95% lyophilized powder. Degree of substitution (DoS): 1 mol % substitution. Other biotin labeling ratio such as 5% can be ordered through custom synthesis.

The biotin substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with biotin groups. You may calculate the number of biotin by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio to get the number of biotin in each HA polymer.


1. Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology12,810–814(2016), Text.

2. Clearance kinetics of biomaterials affects stem cell retention and therapeutic efficacy.  Biomacromolecules 15.2 (2014): 564-573. Text.

3. Biotinylated hyaluronic acid: a new tool for probing hyaluronate-receptor interactions. Bioconjug Chem., 1994, 5(4):370-2.

4. 3. Single-molecule mechanical measurements of the hyaluronan-aggrecan bottle brush, Biomolecules, 2019, arXiv:1910.13576 [q-bio.BM]

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