Catalog No. : HA-608
Product Name : Hyaluronate Spacer Biotin, MW 750k
Description :

Hyaluronic Acid is labeled with biotin through a long chain spacer. The long chain spacer is about 30 angstroms. Purity: >95% lyophilized powder. Degree of substitution: 1 mol % substitution and at least one biotin molecule per HA polymer.

The biotin substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with biotin groups. You may calculate the number of biotin by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio to get the number of biotin in each HA polymer.


1) Biotinylated hyaluronic acid: a new tool for probing hyaluronate-receptor interactions. Bioconjug Chem., 1994, 5(4):370-2.

2) Hyaluronic acid based scaffolds for tissue engineering—A review, Carbohydrate Polymers 2013, 92(2):1262– 1279. 3) An insight on hyaluronic acid in drug targeting and drug delivery, J Drug Target, 2008, 16(2):91-107.

4) Single-molecule mechanical measurements of the hyaluronan-aggrecan bottle brush, Biomolecules, 2019, arXiv:1910.13576 [q-bio.BM]

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