Catalog No. : PSB-301
Product Name : MAL-PEG-MAL, MW 3.4k
Description :

MAL-PEG-MAL is a linear bifunctional PEGylation cross linker with two maleimide groups. MAL selectively reacts with free thiol, sulfhydryl, or mercapto group via Michael addition to form a stable carbon sulfur bond. MAL-PEG-MAL can be used for site specific protein and peptide crosslinking. Hydroquinone at ~ 200 ppm is added as inhibitors.

References: 1. Crosslinking Proteins and Hydrogels - Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries, Front. Chem. 2:23. doi: 10.3389/fchem.2014.00023, Text.

2. Steven R. Tannenbaum, S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration,

3. Solanki, Allison Kiran. Single-molecule force spectroscopy of α-synuclein. Diss. University of Alberta, 2014.

4. Engineering Elastin-like Polypeptide-Poly (ethylene glycol) Multiblock Physical Networks. Biomacromolecules. 2017 Dec. Text.

5. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors. Proceedings of the National Academy of Sciences 115.12 (2018): E2811-E2818, Text.

6. A Combination of Tri-Leucine and Angiopep-2 Drives a Poly-Anionic Polymalic Acid Nanodrug Platform Across the Blood-Brain Barrier, ACS Nano, 2019, doi: 10.1021/acsnano.8b06437.

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